Luisão remains sidelined with a right thigh injury, while Douglas, Keaton Parks, Filipe Augusto and Diogo Gonçalves have all been dropped.
André Almeida, Álex Grimaldo, Ljubomir Fejsa, Pizzi, Eduardo Salvio and Jonas all return after being rested for the League Cup encounter with Vitória de Setúbal.
Wednesday night's crucial Lisbon derby commences at 21:30 local time, and will be officiated by Hugo Miguel.
Goalkeepers: Svilar and Bruno Varela
Defenders: Lisandro, Grimaldo, Eliseu, Jardel, André Almeida and Rúben Dias
Midfielders: Fejsa, Samaris, Źivković, Salvio, Krovinović, Pizzi, Cervi, Rafa Silva and João Carvalho
Forwards: Raúl, Jonas and Seferović