Rui Vitória has made just two changes to his preliminary squad this week: Eliseu is rested, while Andreas Samaris returns after serving his domestic suspension.
Douglas has been left out, presumably to ensure he is 100% fit for the trip to Manchester in midweek, when André Almeida will be suspended. Bruno Varela, Jardel and Rafa Silva remain out of favour.
Friday's match at the Estádio da Luz will commence at 19:00 local time.
Goalkeepers: Svilar and Júlio César
Defenders: Lisandro, Grimaldo, Luisão, André Almeida and Rúben Dias
Midfielders: Fejsa, Filipe Augusto, Samaris, Živković, Salvio, Krovinović, Pizzi, Cervi and Diogo Gonçalves
Forwards: Raúl, Jonas, Gabriel Barbosa, Seferović